Vol. 8 No. 01 (2026), Articles
Vol. 8 No. 01 (2026)

IN VIVO SHAROITIDA KV-BA-1 KON’YUGATINI KALAMUSH JIGAR MITOXONDRIYASI ATFGA BOG‘LIQ KALIY KANAL FAOLLIGIGA TA’SIRI

Articles
Published 2026-02-16
Saidqulova Zarnigor Akmaljon qizi
Qo‘qon davlat universiteti 2-kurs magistranti
Ernazarov Zafarjon Mamurovich
Qo‘qon davlat universiteti Biologiya kafedrasi v.b.dotsenti b.f.f.d. (PhD)
Toshmatova Shoiraxon Ruziyevna
Qo‘qon davlat universiteti Biologiya kafedrasi dotsenti b.f.n.
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Keywords

mitoxondriya, mitoKATF, oksidativ stress (OS), qo‘rg‘oshin xlorid (PbCl₂), kversetin, KV-BA-1 kon’yugati, jigar mitoxondriyasi, in vivo tajribalar, sitoproteksiya

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IN VIVO SHAROITIDA KV-BA-1 KON’YUGATINI KALAMUSH JIGAR MITOXONDRIYASI ATFGA BOG‘LIQ KALIY KANAL FAOLLIGIGA TA’SIRI. (2026). Qo‘qon DPI. Ilmiy Xabarlar Jurnali, 8(01), 58-64. https://doi.org/10.70728/qdpi.v08.i01.008
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Abstract

Mazkur tadqiqotda PbCl₂ yordamida chaqirilgan oksidativ stress sharoitida in vivo tajribalar orqali kalamush jigar mitoxondriyasida ATFga bog‘liq kaliy kanalining (mitoKATF) funksional faolligi hamda uni kversetin va uning asosida sintez qilingan KV-BA-1 kon’yugati yordamida korreksiyalash imkoniyatlari o‘rganildi. Oksidativ stress ta’sirida mitoKATF-kanali o‘tkazuvchanligining sezilarli darajada ingibirlanishi aniqlandi. Kversetin bilan korreksiyalash mitoKATF-kanali faolligini qisman tiklagan bo‘lsa, KV-BA-1 kon’yugati ushbu kanal o‘tkazuvchanligini yanada samarali faollashtirib, mitoxondriya membrana barqarorligi va K⁺ ionlari oqimini yaxshilashi kuzatildi. Olingan natijalar KV-BA-1 kon’yugatining oksidativ stress sharoitida mitoxondriya sitoproteksiyasini ta’minlovchi va bioenergetik barqarorlikni tiklovchi istiqbolli farmakologik modulyator ekanligini ko‘rsatadi

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