Vol. 8 No. 9 (2026), Articles
Vol. 8 No. 9 (2026)

MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE

Articles
Published 2026-10-10
Javokhirkhon Akhatov
Termez state university , doctoral student
Khayit Turaev
Termez state university, Doctor of Chemical science , professor
Jamshid Ashurov
Institute of Bioorganic Chemistry named after Academician Obid Sodikov Academy of Sciences of the Republic of Uzbekistan Doctor of Chemical science , professor
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Keywords

kobalt(II) kompleksi
tiosemikarbazon
molekulyar docking
kandidapepsin-5
ROP18
redocking validatsiyasi
konsensus ballash

How to Cite

MOLECULAR DOCKING OF A COBALT(II) BIS-CHELATE OF PHENYLGLYOXYLIC ACID THIOSEMICARBAZONE AGAINST A FUNGAL ASPARTIC PROTEASE AND A PROTOZOAN KINASE. (2026). Qo‘qon DPI. Ilmiy Xabarlar Jurnali, 8(9), 1551-1560. https://doi.org/10.70728/a.series.tab.v08.i09.200
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Abstract

Kobalt(II) bis-xelati Co(PGTS)₂ Candida albicans kandidapepsin-5 va Toxoplasma gondii ROP18 kinazasiga dock qilindi. Ikkala nishonda ham kompleks erkin ligandning ikki shaklidan past ball oldi. Hal qiluvchi cheklov shundaki, hech bir retseptor redocking nazoratidan o‘tmadi: 2QZX da nazoratni o‘tkazish mumkin emas, 4JRN da esa u 3.31 Å bilan muvaffaqiyatsiz bo‘ldi. Metall atomining turi natijani umuman o‘zgartirmadi, Vinardo funksiyasi esa Vina tartibini bironta nishonda ham takrorlamadi. Shu sababli natijalar validatsiyalanmagan protokol bo‘yicha prognoz sifatida beriladi va avvalo metodik davomiy tekshirishni talab qiladi.
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