Vol. 8 No. 9 (2026), Articles
Vol. 8 No. 9 (2026)

FENILGLIOKSIL KISLOTA TIOSEMIKARBAZONINING KOBALT(II) BIS- XELATINI BAKTERIAL NISHONLARGA MOLEKULYAR DOCKING QILISH

Articles
Published 2026-10-10
Javokhirkhon Akhatov
Termez state university , doctoral student
Khayit Turaev
Termez state university, Doctor of Chemical science , professor
Jamshid Ashurov
Institute of Bioorganic Chemistry named after Academician Obid Sodikov Academy of Sciences of the Republic of Uzbekistan Doctor of Chemical science , professor
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Keywords

kobalt(II) kompleksi
tiosemikarbazon
molekulyar docking
AutoDock

How to Cite

FENILGLIOKSIL KISLOTA TIOSEMIKARBAZONINING KOBALT(II) BIS- XELATINI BAKTERIAL NISHONLARGA MOLEKULYAR DOCKING QILISH. (2026). Qo‘qon DPI. Ilmiy Xabarlar Jurnali, 8(9), 1540-1550. https://doi.org/10.70728/a.series.tab.v08.i09.199
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Abstract

Kobalt(II) bis-xelati Co(PGTS)₂ ning rentgen tuzilishidan o‘zgarmagan geometriyasi yettita bakterial nishonga molekulyar docking usulida tekshirildi. Oltitasi har qanday ball hisoblanishidan oldin muzlatilgan protokol asosida dock qilindi va oltitasi ham redocking validatsiyasidan o‘tdi. Kompleks oltitadan to‘rttasida erkin ligandning ikki shaklidan ham past ball oldi, eng kuchli ajralish Bacillus subtilis FtsZ (2RHL) da qayd etildi. Metall atomining turi natijani umuman o‘zgartirmadi. Vinardo funksiyasi bilan qayta ballash Vina tartibini faqat bitta nishonda takrorladi va bu xulosani sezilarli darajada cheklaydi.
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