Keywords
3-d]pyrimidinones
ethynyl derivatives
palladium catalysts
copper(I) iodide
NMR spectroscopy
cesium carbonate
tetrahydrofuran.
How to Cite
Abstract
This study investigates the Sonogashira cross-coupling reactions of 3- bromo-pyrido[2,3-d]pyrimidinone derivatives with terminal alkynes. The research was conducted in an inert atmosphere using a palladium catalyst and copper(I) iodide as a co- catalyst. The effects of various factors, including the catalyst system, base, solvent, and the structure of the alkynes, on the reaction efficiency were evaluated. The results demonstrate that the 3-bromo-pyrido[2,3-d]pyrimidinone scaffold exhibits sufficient reactivity in Sonogashira cross-coupling, yielding the corresponding ethynyl-substituted derivatives in moderate to high yields. The structures of the synthesized compounds were reliably confirmed by 1H and 13C NMR spectroscopy, mass spectral analysis, and melting point (MP) measurements.References
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