Keywords
3
4-tiadiazolin-2-tion
malein angidridi
N-atsil
yupqa qatlamli xromatografiya
trietilamin
IQ-spektroskopiya
UB-Vis spektroskopiya
biologik faollik
PASS
in silico tahlil.
How to Cite
Abstract
Ushbu tadqiqotda 5-o-toluidino-, 5-n-butilamino- va 5-α-naftilamino- 1,3,4-tiadiazolin-2-tionlarning malein angidridi bilan o‘zaro ta’siri o‘rganilib, yangi N-atsil hosilalarni sintez qilish hamda ularning tuzilishini va nazariy jihatdan biologik xususiyatlarini baholash maqsad qilingan. Reaksiyalar trietilamin ishtirokida absolyut benzol erituvchisida xona harorati va 80℃ da amalga oshirildi. Sintez qilingan mahsulotlarining tuzilishi IQ- va UB-Vis spektroskopik tahlillari, fizik-kimyoviy ko‘rsatkichlari asosida tavsiflandi. Sintez qilingan birikmalarning nazariy biologik faolligi PASS dasturi yordamida in silico baholandi. Olingan natijalar 1,3,4-tiadiazolin-2-tion molekulasini malein angidridi bilan atsillash orqali yangi biologik faol birikmalar sintez qilish imkoniyatini yaratib, ularning keyingi tadqiqotlar uchun istiqbolli birikmalar ekanligini ko‘rsatadi.References
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