Keywords
aminobirikma
supramolekulyar kompleks
spektroskopik tahlil
tadqiqotning fizik-kimyoviy usullari.
How to Cite
Abstract
Oleanol kislota va uning hosilalari o‘simliklarda keng tarqalgan pentahalqali triterpenoidlar bo‘lib, antioksidant, gepatoprotektor, yallig‘lanish, bakteriya va saratonga qarshi biologik faolliklarni namoyon qiladi. Ushbu ilmiy tadqiqotning maqsadi oleanol kislotaning turli aminobirikmalar bilan supramolekulyar komplekslarini olish va ularning tuzilish xususiyatlarini spektroskopik hamda mass-spektrometrik usullar yordamida baholashdan iborat. Oleanol kislotaning 4-aminoantipirin, 2-aminotiazol, 2-aminofenol, 4- amino-4H-1,2,4-triazol, 2-amino-1,3,4-tiadiazol va uning alkil hosilalari bilan supramolekulyar komplekslari olindi. Olingan komplekslar IQ- va UB-spektroskopiyasi hamda mass-spektrometriya usullari yordamida tavsiflandi.References
1. Alam, M. S., Choi, J., & Lee, D. (2012). Synthesis of novel Schiff base analogues of 4-amino-1,5-dimethyl-2-phenylpyrazol-3-one and their evaluation for antioxidant and anti- inflammatory activity. Bioorganic Medicinal Chemistry, https://doi.org/10.1016/j.bmc.2012.04.058
2. Esanov, R. S., Bobakulov, K. M., Abdullaev, N. D., Gafurov, M. B., & Yuldashev, K. A. (2021). Synthesis of New 18β-H-Glycyrrhetic Acid Amides with Several 2-Amino-5- Alkylaminothiadiazoles. Chemistry Natural Compounds, 335–338. https://doi.org/10.1007/s10600-021-03345-7
3. Esanov, R., Dzhuraev, A., Rafikova, K., Khashimova, Z., Berdibaev, E., Abdurazzakova, D. S., & Matchanov, A. (2024). Synthesis and biological activity of some esters glycyrretinic acid. Engineered Science. 31. 1212. 1-8. https://doi.org/10.30919/es1212
4. Fu, L., Lin, Q., Onyango, E. O., Liby, K. T., Sporn, M. B., & Gribble, G. W. (2017). Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids. Organic Biomolecular Chemistry, 6001–6005. https://doi.org/10.1039/c7ob01420a
5. Makhova, N. N., Belen’kii, L. I., Gazieva, G. A., Dalinger, I. L., Konstantinova, L. S., Kuznetsov, V. V., Kravchenko, A. N., Krayushkin, M. M., Rakitin, O. A., Starosotnikov, A. M., Fershtat, L. L., Shevelev, S. A., Shirinian, V. Z., & Yarovenko, V. N. (2019). Progress in the chemistry of nitrogen-, oxygen- and sulfur-containing heterocyclic systems. Russian Chemical Reviews, 89(1), 55–124. https://doi.org/10.1070/rcr4914
6. Medvedeva, N. I., Kazakova, O. B., Lopatina, T. V., Smirnova, I. E., Giniyatullina, G. V., Baikova, I. P., & Kataev, V. E. (2017). Synthesis and antimycobacterial activity of triterpenic A-ring azepanes. European Journal of Medicinal Chemistry, 143, 464–472. https://doi.org/10.1016/j.ejmech.2017.11.035
7. Naz, A., Haider, S., Rana, M., Malik, N., Afzal, A., Farooq, M., & Sarfraz, M. (2025). Quantification of oleanolic acid and apigenin in biological matrices following intraperitoneal administration of co-loaded nanoformulations: Method validation and biodistribution studies. Talanta Open, 100470. https://doi.org/10.1016/j.talo.2025.100470
8. Neha, K., Haider, M. R., Pathak, A., & Yar, M. S. (2019). Medicinal prospects of antioxidants: A review. European Journal of Medicinal Chemistry, 178, 687–704. https://doi.org/10.1016/j.ejmech.2019.06.010
9. Tilyabaev, Z., Khashimova, М., Mathur, V., Esanov, R., Gafurov, М., & Rustamov, K. (2023). The licorice (Glycyrrhiza glabra L.) metabolite derivatives as bioinsecticides against Аnacanthotermes turkеstanicus termites. E3S Web of Conferences, 434, 03024. P. 1-
10. https://doi.org/10.1051/e3sconf/202343403024 10. 10. Vyas N., Argal A. Isolation and characterization of oleanolic acid from roots of Lantana camara //Asian J Pharm Clin Res. – 2014. – Т. 7. – №. Suppl 2. – P. 189-191.