Keywords
kalamush
yurak ishemiyasi
miokard shikastlanishi
miokard infarkti
oksidlovchi stress
lipid peroksidlanishi
yallig‘lanish.
How to Cite
Abstract
Mazkur maqolada tajriba sharoitida kalamushlarda yurak ishemiyasini chaqirish modeli sifatida izoproterenoldan foydalanishning zamonaviy yondashuvlari tahlil qilingan. Izoproterenol β-adrenergik retseptorlarning kuchli agonisti bo‘lib, uning yuqori dozada yuborilishi yurak qisqarishlari va miokardning kislorodga bo‘lgan ehtiyojini oshirishi, natijada miokardda metabolik va oksidlovchi stress, lipid peroksidlanishi hamda strukturaviy-funksional o‘zgarishlarning rivojlanishiga olib kelishi mumkin. Maqolada izoproterenol yordamida eksperimental yurak ishemiyasini modellashtirishning nazariy asoslari, ushbu modelning afzalliklari va cheklovlari yoritilgan. Adabiyotlar tahlili izoproterenol modeli miokard shikastlanishi, oksidlovchi stress va kardioprotektiv vositalarning samaradorligini o‘rganishda keng qo‘llaniladigan eksperimental yondashuvlardan biri ekanligini ko‘rsatadi.References
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