Keywords
norstiktik kislota
aspitsilin
depsidon
makrolid
metallorganik kompleks
supramolekulyar kimyo
endolishen zamburug‘
antioksidant faollik
saksikol lishaynik.
How to Cite
Abstract
Ushbu maqolada Aspicilia cinerea (Megasporaceae) lishaynigining ikkilamchi metabolitlari, biologik faolligi, uning tarkibidagi birikmalar (birinchi navbatda norstiktik kislota va aspitsilin makrolidi) asosida metallorganik hamda supramolekulyar birikmalar sintezining metodologiyasi va istiqbollari, shuningdek ushbu lishaynikning endolishen zamburug‘larining kimyoviy tarkibi va biologik faolligi bo‘yicha so‘nggi o‘n yildagi ilmiy adabiyotlar tahlil qilingan. A. cinerea ning asosiy metaboliti norstiktik kislota bo‘lib, u orto-holatdagi erkin gidroksil va karbonil guruhlari tufayli metall ionlari bilan barqaror xelat hosil qilishga qodir; bu esa uni koordinatsion kimyo uchun istiqbolli ob'ekt qiladi. Tahlil natijasida norstiktik kislotaning turli metall komplekslari va aspitsilin asosidagi supramolekulyar tizimlar kam o‘rganilgan ilmiy bo‘shliq ekanligi aniqlandi.References
1. Ureña-Vacas I., González-Burgos E., Divakar P.K., Gómez-Serranillos M.P. (2023). Lichen Depsides and Tridepsides: Progress in Pharmacological Approaches // Journal of Fungi. Vol. 9, № 1. – Article 116. – P. 1–28.
2. Ranković B., Kosanić M. (2019). Lichens as a Potential Source of Bioactive Secondary Metabolites // Lichen Secondary Metabolites: Bioactive Properties and Pharmaceutical Potential. – Cham: Springer. – P. 1–29.
3. Calcott M.J., Ackerley D.F., Knight A., Keyzers R.A., Owen J.G. (2018). Secondary metabolism in the lichen symbiosis // Chemical Society Reviews. Vol. 47, № 5. – P. 1730–1760.
4. Wang X., Qin X., Hao Z. et al. (2025). A Comprehensive Review on Chemical Structures and Bioactivities of Ostropomycetidae Lichens // Journal of Fungi. Vol. 11, № 5. – Article 369.
5. Nordin A., Tibell L., Owe-Larsson B. (2007). A preliminary phylogeny of Aspicilia in relation to morphological and secondary product variation // Bibliotheca Lichenologica. Vol. 96. – P. 247–266.
6. Paukov A., Teptina A., Morozova M. et al. (2016). Accumulation of metals in crustose lichens growing on serpentinite // Turczaninowia. Vol. 19, № 1. – P. 62–70.
7. Purvis O.W., Elix J.A., Broomhead J.A., Jones G.C. (1987). The Occurrence of Copper–norstictic Acid in Lichens from Cupriferous Substrata // The Lichenologist. Vol. 19, № 2. – P. 193–203.
8. Hauck M., Jürgens S.-R., Willenbruch K. et al. (2009). Dissociation and metal-binding characteristics of yellow lichen substances // Annals of Botany. Vol. 103, № 1. – P. 13–22.
9. Frei A., Zuegg J., Elliott A.G. et al. (2020). Metal complexes as a promising source for new antibiotics // Chemical Science. Vol. 11, № 10. – P. 2627–2639.
10. Damena T., Zeleke D., Desalegn T. et al. (2022). Synthesis, characterization, and biological activities of zinc(II), copper(II) and nickel(II) complexes of an aminoquinoline derivative // Frontiers in Chemistry. Vol. 10. – Article 1053532.
11. Selyutina O.Yu., Polyakov N.E. (2019). Glycyrrhizic acid as a multifunctional drug carrier // International Journal of Pharmaceutics.Vol. 559. – P. 271–279.
12. Wethalawe A.N., Alwis Y.V., Udukala D.N., Paranagama P.A. (2021). Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review // Molecules. Vol. 26, № 13. – Article 3901.
13. Zhao Q., Wang G.-Q., Wang Y. et al. (2024). Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules – An Update // Journal of Fungi. Vol. 10, № 2. – Article 99.
14. Ranković B., Kosanić M., Stanojković T. et al. (2012). Biological Activities of Toninia candida and Usnea barbata Together with Their Norstictic Acid and Usnic Acid Constituents // International Journal of Molecular Sciences. Vol. 13, № 11. – P. 14707–14722.
15. Oh S.-O., Wang X.-Y., Kondratyuk T.P. et al. (2022). A new lichen-forming fungus, Aspicilia humida, from a forested wetland in South Korea, with a taxonomic key for aspicilioid species // Mycobiology. Vol. 50, № 1. – P. 20–29.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2026 Gulnozaxon Islom qizi Qoraboyeva (Author)