Keywords
konfluentik kislota
norstiktik kislota
depsid
depsidon
metallorganik kompleks
supramolekulyar kimyo
endolishen zamburug‘
antimikrob faollik
saksikol lishaynik.
How to Cite
Abstract
Ushbu maqolada Lecidea atrobrunnea (Lecideaceae) lishaynigining ikkilamchi metabolitlari, biologik faolligi, uning tarkibidagi depsid va depsidonlar (konfluentik va norstiktik kislotalar) asosida metallorganik hamda supramolekulyar birikmalar sintezining metodologiyasi va eng samarali usullari, sintez qilingan birikmalarning biologik faolligi, shuningdek ushbu lishaynikning endolishen zamburug‘larining kimyoviy tarkibi va biologik faolligi bo‘yicha so‘nggi o‘n yildagi ilmiy adabiyotlar tahlil qilingan. L. atrobrunnea ning ham konfluentik, ham norstiktik kislotani saqlashi uni metall koordinatsion kimyosi uchun ayniqsa qiziqarli ob’ekt qiladi: norstiktik kislotaning mis kompleksi tasdiqlangan bo‘lsa-da, konfluentik kislotaning metall komplekslari deyarli o‘rganilmagan. Bu esa yangi biologik faol koordinatsion va supramolekulyar birikmalar yaratish uchun istiqbolli ilmiy yo‘nalishni belgilaydi.References
1. Ureña-Vacas I., González-Burgos E., Divakar P.K., Gómez-Serranillos M.P. (2023). Lichen Depsides and Tridepsides: Progress in Pharmacological Approaches // Journal of Fungi. Vol. 9, № 1. – Article 116. – P. 1–28.
2. Ranković B., Kosanić M. (2019). Lichens as a Potential Source of Bioactive Secondary Metabolites // Lichen Secondary Metabolites: Bioactive Properties and Pharmaceutical Potential. – Cham: Springer. – P. 1–29.
3. Calcott M.J., Ackerley D.F., Knight A., Keyzers R.A., Owen J.G. (2018). Secondary metabolism in the lichen symbiosis // Chemical Society Reviews. Vol. 47, № 5. – P. 1730–1760.
4. Fryday A.M., Hertel H. (2014). A contribution to the family Lecideaceae s. lat. // The Lichenologist. Vol. 46, № 1. – P. 41–75.
5. Gowan S.P. (1989). The lichen genus Porpidia (Porpidiaceae) in North America // The Bryologist. Vol. 92, № 1. – P. 25–59.
6. Ren Q., Liu L., Zhao X. (2025). Morphology, chemistry, and phylogeny reveal three new species of Lecidea (Lecideaceae) from China // MycoKeys. Vol. 100. – P. 1–24.
7. Purvis O.W., Elix J.A., Broomhead J.A., Jones G.C. (1987). The Occurrence of Copper–norstictic Acid in Lichens from Cupriferous Substrata // The Lichenologist. Vol. 19, № 2. – P. 193–203.
8. Hauck M., Jürgens S.-R., Willenbruch K. et al. (2009). Dissociation and metal-binding characteristics of yellow lichen substances // Annals of Botany. Vol. 103, № 1. – P. 13–22.
9. Frei A., Zuegg J., Elliott A.G. et al. (2020). Metal complexes as a promising source for new antibiotics // Chemical Science. Vol. 11, № 10. – P. 2627–2639.
10. Damena T., Zeleke D., Desalegn T. et al. (2022). Synthesis, characterization, and biological activities of zinc(II), copper(II) and nickel(II) complexes of an aminoquinoline derivative // Frontiers in Chemistry. Vol. 10. – Article 1053532.
11. Selyutina O.Yu., Polyakov N.E. (2019). Glycyrrhizic acid as a multifunctional drug carrier // International Journal of Pharmaceutics.Vol. 559. – P. 271–279.
12. Wethalawe A.N., Alwis Y.V., Udukala D.N., Paranagama P.A. (2021). Antimicrobial Compounds Isolated from Endolichenic Fungi: A Review // Molecules. Vol. 26, № 13. – Article 3901.
13. Zhao Q., Wang G.-Q., Wang Y. et al. (2024). Endolichenic Fungi: A Promising Medicinal Microbial Resource to Discover Bioactive Natural Molecules – An Update // Journal of Fungi. Vol. 10, № 2. – Article 99.
14. Favero-Longo S.E., Gazzano C., Girlanda M. et al. (2013). Biocidal effect of lichen secondary metabolites against rock-dwelling microcolonial fungi, cyanobacteria and green algae // International Biodeterioration & Biodegradation. Vol. 84. – P. 384–392.
15. Teptina A., Paukov A., Nascimbene J. (2019). The Effects of Edaphic and Climatic Factors on Secondary Lichen Chemistry: A Case Study Using Saxicolous Lichens // Diversity. Vol. 11, № 6. – Article 94.
16. Studzińska-Sroka E., Majchrzak-Celińska A., Zalewski P. et al. (2021). Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties // Pharmaceuticals. Vol. 14, № 12. – Article 1293.
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright (c) 2026 Gulnozaxon Islom qizi Qoraboyeva (Author)