Keywords
Shiff asoslari
metall komplekslari
koordinatsion kimyo
antimikrob faollik
DFT hisoblashlari
biodegradatsiya.
How to Cite
Abstract
Sulfanilamidlar sinfiga mansub sulfametoksazol (SMX) va uning trimetoprim (TMP) bilan kombinatsiyalari zamonaviy tibbiyot va farmatsevtikada keng qo‘llaniladigan antibakterial dori vositalaridan biri hisoblanadi. Biroq, so‘nggi klinik tadqiqotlar SMX-TMP preparatlarini amaliyotda qo‘llashda teri toshmalari, gematologik asoratlar hamda metabolik buzilishlar kabi qator nojo‘ya ta’sirlarning yuqori xavfi mavjudligini ko‘rsatmoqda. Ushbu tadqiqotning maqsadi sulfametoksazol molekulasini Shiff asoslariga aylantirish hamda ularning 3d metallari va lantanidlar bilan koordinatsion komplekslarini sintez qilish orqali biologik samaradorlikni oshirish va toksiklikni kamaytirishga bag‘ishlangan ilmiy natijalarni tizimlashtirishdan iborat. Xalqaro va Oʻzbekiston ilmiy jurnallari tahlili shuni ko‘rsatdiki, SMX va uning hosilalari metall kationlari bilan bidentat hamda polidentat tarzda koordinatsiyalanib, oktaedrik va yuqori koordinatsion geometriyali komplekslarni hosil qiladi. Spektroskopik (IQ, UB-ko‘rinuvchi, PMR, EPR), TGA hamda zichlik funksionali nazariyasi (DFT) hisoblashlari bog‘lanish asosan sulfonil kislorodi, imin va izoksazol azoti orqali amalga oshishini tasdiqlaydi. In vitro va molekulyar doking tadqiqotlari natijalariga ko‘ra, metall komplekslari va Shiff asoslari dastlabki dori vositalariga nisbatan patogen bakteriya va zamburug‘larga qarshi yuqori antimikrob, antioksidant hamda saratonga qarshi faollik namoyon etadi. Shuningdek, SMX va uning xlorli hosilalarining sun’iy suv-botqoq yerlarda biodegradatsiyaga uchrash yo‘llari hamda ekologik xavfsizligi tahlil qilingan.References
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Copyright (c) 2026 Z.Sh. Abdullayeva, L.X. Roʻzimova, H.M. Ismoilova (Author)