Vol. 8 No. 6 (2026), Articles
Vol. 8 No. 6 (2026)

COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX

Articles
Published 2026-07-13
Abduvali Bakhodir Ugli Khushbokov
Doctoral student of Termez State University, Termez
Khayit Khudoynazarovich Turayev
Doctor of Chemical Sciences, Professor, Termez State University, Termez
Ibragim Amonovich Umbarov
Doctor of technical sciences, professor, Termez State University, Termez
Odil Irgashevich Choriyev
Doctor of Philosophy in Chemical Sciences, Institute of Bioorganic Chemistry, Uzbekistan Academy of Sciences, Tashkent.
Jamshid Mengnorovich Ashurov
Doctor of Chemical Sciences, Professor, Institute of Bioorganic Chemistry, Academy of Sciences of Uzbekistan, Tashkent.
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Keywords

benzotiazol hosilalari
kobalt(II) kompleksi
SwissADME
in silico tahlil
fizik-kimyoviy xossalar
farmakokinetik profil
drug-likeness
medicinal chemistry
ADME
biofoydalanuvchanlik.

How to Cite

COMPREHENSIVE IN SILICO EVALUATION OF THE PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETIC PROFILE, AND DRUG-LIKENESS OF A NEWLY SYNTHESIZED DICHLOROBIS(6-METHOXY-1,3-BENZOTHIAZOL-2- AMINE)COBALT(II) COMPLEX. (2026). Qo‘qon DPI. Ilmiy Xabarlar Jurnali, 8(6), 801-815. https://doi.org/10.70728/a.series.tab.v08.i06.109
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Abstract

Mazkur tadqiqotda yangi sintez qilingan dichlorobis(6-methoxy-1,3- benzothiazol-2-amine)cobalt(II) kompleksining fizik-kimyoviy xossalari, farmakokinetik profili, dori vositasiga o'xshashlik (drug-likeness) hamda medicinal chemistry ko'rsatkichlari SwissADME onlayn platformasi yordamida in silico usulda kompleks baholandi. Molekulyar tavsiflar, lipofillik, suvda eruvchanlik, ADME parametrlari, farmakokinetik xususiyatlar va dori vositasiga o'xshashlik mezonlariga muvofiqligi tizimli ravishda tahlil qilindi. Tadqiq etilgan kompleks o'rtacha lipofillik, qulay strukturaviy xususiyatlar hamda PAINS va Brenk ogohlantirishlarining mavjud emasligi bilan tavsiflandi. Suvda eruvchanlikning pastligi, oshqozon-ichak traktida so'rilishning cheklanganligi va ayrim empirik drug-likeness mezonlari bo'yicha kichik chetlanishlar aniqlangan bo'lsa-da, ushbu natijalar o'tish metallari koordinatsion birikmalarining o'ziga xos fizik-kimyoviy xususiyatlari bilan izohlanadi. Olingan natijalar tadqiq etilgan kobalt(II) kompleksining farmatsevtik istiqbolini nazariy jihatdan baholash hamda keyingi in vitro, in vivo va molekulyar docking tadqiqotlari uchun ilmiy asos yaratadi.
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