Keywords
membrane permeability
CsA-sensitive pore
lipid peroxidation
oxidative phosphorylation
antioxidants
prooxidants
free radicals
apoptosis
necrosis
glycyrrhetic acid derivatives.
How to Cite
Abstract
In the article, the effect of new synthetic derivatives of glycyrrhetic acid on the functional parameters of mitochondria, as well as the parameters of the CsA-sensitive pore of mitochondrial membranes, were studied. It is shown for the first time that derivatives of glycyrrhetic acid - 2-(N-cytisine)-ethyl-3-0-acetyl-18H-glycyrrhetate, 2-(N-cytisine)-isopropyl- 3-0-acetyl-18H-glycyrrhetate and N-(2-pyridyl)-3-0-acetyl-11-ketoolean-12-en-30-amide inhibit the activity of the CsA-sensitive pore and have a protective effect on mitochondrial membranes.References
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