Keywords
xloratsetilxlorid
4-gidroksiatsetanilid
xloratsetillash
TAA
MoCl5
FeCl3.
How to Cite
Abstract
Turli funksional guruh saqlagan atsetanilidni xlorasetillash mavzusi bo’yicha jahon adabiyotlarida tarkibida aromatik halqa va N,O atomlarini saqlovchi organik birikmalarni xloratsetillash reaksiyalari bo’yicha qilingan ilmiy ishlar bo’yicha ma’lumotlar to’plandi. Atsetanilidning OH guruhini saqlagan hosilasi 4-gidroksiatsetanilidni xloratsetilxlorid bilan atsillashning muqobil sharoitlarini topish maqsadida turli erituvchilar va katalizatorlar ishtirokida reaksiyalar olib borildi. 4-Gidroksiatsetanilidni xloratsetillash reaksiyalarida katalizatorlar uchun yuqori unum olish sharoitlari topildi va reaksiyaning unumiga ko‘ra katalizatorlar faolligi qatori aniqlandi: TAA< MoCl5< FeCl3References
1. Abdushukurov A.K., Mamatqulov N.N., Choriev A.U. Aromatik xloratsetil birikmalar: olinishi, xossalari, qo'llanilishi. Monografiya // -2019. -3-153 b.
2. Fatma K., Filiz A. 4-aril aminobifenilglioksimlar va ularning komplekslarining sintezi va tavsifi // J. Chil. Chem. Soc.- 2006. 51-jild. № 3. -B. 982-985
3. Manasa H.S., Deepashree C.L., Shubha G. va Shashikanth S. Fosforli Pentoksid va metan sulfon kislotasi ishtirokida Friedel Craftning atsilatsiyasi orqali (3-Gidroksi-2,4-dimetoksifenil) (fenil) metanonlarning oson sintezi va antibakterial faolligi: Eaton reagenti// Xalqaro farmatsevtika, kimyo va biologiya fanlari jurnali, - 2015. -5-jild. № 3. -742-747.
4. Liu X.H., Cui P., Song B.A., Bhadury P.S., Zhu H.L., Wang S.F. Synthesis, structure and antibacterial activity of novel 1-(5-substituted-3- substituted-4,5-dihydropyrazol-1-yl)ethanone oxime ester derivatives // Bioorgan. Med. Chem. 2008. -№16.-P. 4075-4082.
5. Riyadh S.M., Farghaly T.A., Abdallah M.A., Abdalla M.M., El-Aziz M.R. New pyrazoles incorporating pyrazolylpyrazole moiety: Synthesis, anti-HCV and antitumor activity // Eur. J. Med. Chem. 2010. - № 45.-P. 1042-1050.
6. Huang K.H., Veal J.M., Fadden P.R., Rice J.W., Eaves J., Strachan J.P., Barabasz A.F., Foley B.E., Barta T.E., Discovery of Novel 2-Aminobenzamide Inhibitors of Heat Shock Protein 90 as Potent, Selective and Orally Active Antitumor Agents // J. Med. Chem. -2009. № 52. -Р. 4288–4305.
7. Mohareb R.M., Samir E.M. The Reaction of cyanoacetylhydrazine with chloroacetone: Synthesis of 1,2,4-triazine, 1,3,4-oxadiazine and their fused derivatives with antitumor activities // Open J. Med. Chem. -2012. № 2. -P. 1–9.
8. Fattakhova I.Ya., Meshcheryakova S.A., Kataev V.A. Syntez novykh №- phenylacetamidnykh proizvodnykh thietanylpyrimidine-2,4(1N,ZN)-dione // Bashkirskiy khimicheskii zurnal. -2014. -T. 21. - No. 3. -C 33-36
9. Фаттахова И.Я. Синтез биологически активных ацетамидных производных 6-метилпиримидин-2, 4(1Н,ЗН)-диона, содержащих тиетановый цикл // Диссертация на соискание ученой степени кандидата химических наук. Уфа - 2015. -С. 45.
10. A.K.Abdushukurov, X.F. Shaxriyev p-atsetilaminofenolni Lyuis kislotalari ishtirokida xloratsetillash reaksiyalari “O’zbekistonda tabiiy birikmalar kimyosining rivoji va kelajagi” respublika ilmiy-amaliy konferensiyasi materiallari to’plami. 18-19 may 2016 y. Toshkent 2016. 400 bet.