Abstract
Tadqiqot acetilen saqlagan karbamat hosilalarining laboratoriya kalamushlarining immun-sitokin javobiga ta’sirini baholashga qaratilgan. O‘tkir yallig‘lanish formalin yordamida modellashtirildi. Qon zardobida proyallig‘lanish (IL-6, FNO-α) va antiinflamator (IL-4) sitokinlar ELISA yordamida o‘lchandi. Natijalar karbamat hosilalarining yallig‘lanish mediatorlarini kamaytirib, sitokin balansini antiinflamator yo‘nalishga siljitishini ko‘rsatdi. Ushbu birikmalar immunomodulyator va yallig‘lanishga qarshi vositalar sifatida istiqbolli hisoblanadi.
References
1.Yakubxodjaeva M.R. Atsetilen fragmenti saqlagan karbamat hosilalarining yallig‘lanishga qarshi faolligi // Tibbiyot va biologiya muammolari. – Toshkent, 2023. – №2. – B. 45–52.
2.Abbas A.K., Lichtman A.H., Pillai S. Cellular and Molecular Immunology. – 10th ed. – Elsevier, 2021.
3.Dinarello C.A. Proinflammatory cytokines // Chest. – 2000. – Vol. 118(2). – P. 503–508.
4.Turner M.D., Nedjai B., Hurst T., Pennington D.J. Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease // Biochimica et Biophysica Acta. – 2014. – Vol. 1843(11). – P. 2563–2582.
5.Barnes P.J. Anti-inflammatory actions of glucocorticoids: molecular mechanisms // Clinical Science. – 1998. – Vol. 94. – P. 557–572.
6.Medzhitov R. Origin and physiological roles of inflammation // Nature. – 2008. – Vol. 454. – P. 428–435.
This work is licensed under a Creative Commons Attribution 4.0 International License.