Abstract
Ushbu tadqiqot d-metallarning biologik faol ligandlar bilan aralash ligandli koordinatsion birikmalarini maqsadli sintez qilish va ularning tarkibiy tuzilishini o‘rganishga bag‘ishlangan. Tadqiqot obyekti sifatida Co(II), Ni(II) va Cu(II) ionlarining sulfanilamid hamda nikotinamid bilan hosil qilgan aralash ligandli komplekslari tanlab olindi. Kompleks birikmalar sintezi suvli va etil spirtli muhitlarda, reagentlarning stexiometrik nisbatlarini aniqlash orqali amalga oshirildi. Olingan mahsulotlarning individualligi, elementar tarkibi va fizik-kimyoviy parametrlari zamonaviy tahlil usullari, xususan, element tahlili va IQ-spektroskopiya yordamida o‘rganildi.
IQ-spektroskopik tadqiqotlar natijasida ligandlarning metall markazi bilan koordinatsiyalanish usullari aniqlandi. Sulfanilamid molekulasining donor markazlari (aminoguruhi yoki sulfonamid guruhidagi azot/kislorod atomlari) hamda nikotinamidning piridin halqasidagi azot atomi orqali koordinatsiyalanishi natijasida yuzaga kelgan xarakterli yutilish tasmalarining (ν(NH2), ν(SO2), ν(C=N) va ν(M-N)) yuqori chastotaga yoki past chastotaga siljishlari tahlil qilindi.
References
1. Blasco F., Perelló L., Latorre J., et al. Cobalt(II), Nickel(II), and Copper(II) complexes of sulfanilamide derivatives: synthesis, spectroscopic studies, and antibacterial activity // Journal of Inorganic Biochemistry. – 1996. – Vol. 61. – No. 2. – P. 143–154.
2. Palenik G. J., Sullivan D. A., Naik D. V. A ligand-induced proton shift (LIPS) in two cobaloxime complexes: crystal and molecular structures // Journal of the American Chemical Society. – 1975. – Vol. 97. – No. 6. – P. 1416–1424.
3. Azhari S. J., Mlahi M. R., Al-Asmy A. A., et al. Synthesis of novel binary and ternary complexes derived from 1-(2-hydroxy benzoyl)-4-phenylthiosemicarbazide and 2,2'-dipyridyl with Co(II), Cu(II) and Zn(II) salts // Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. – 2015. – Vol. 136. – P. 1360–1368.
4. Allan J. R., Paton A. D., Turvey K., et al. Synthesis and thermal studies of nicotinamide complexes of some first row transition metal ions // Thermochimica Acta. – 1988. – Vol. 124. – P. 345–355.
5. Fadeeva V. P., Tikhova V. D., and Nikulicheva O. N. Elemental Analysis of Organic Compounds with the Use of Automated CHNS Analyzers // Journal of Analytical Chemistry, 2008, -V.63(11), -P.1094–1106.
6. Ефимова А.И., Головань Л.А., Кашкаров П.К., Сенявин В.М., Тимошенко В.Ю. Инфракрасная спектроскопия систем пониженной размерности: Учебное пособие. — Санкт-Петербург: Изд-во «Лань», 2016. — 246 с.
7. Nakamoto K. Infrared and Raman Spectra of Inorganic and Coordination Compounds, Part B: Applications in Coordination, Organometallic, and Bioinorganic Chemistry. – 6th ed. – Hoboken: Wiley, 2009. – 424 p.
8. Bellamy, L. J. Infrakrasnyye spektry slozhnykh molekul [The Infra-red Spectra of Complex Molecules]. – Moscow: Inostrannaya Literatura, 1963. – 592 p. (In Russian).
This work is licensed under a Creative Commons Attribution 4.0 International License.