Abstract
Ushbu maqolada 2-amino-5-metil-1,3-tiazol (2a-5mt) va CoCl₂ ishtirokida sintez qilingan yangi [Co(2a-5mt)₄Cl]Cl kompleksi o‘rganildi. Birikma kvadrat-piramidal geometriyada (koordinatsion son 5, P4/ncc fazoviy guruhi), markaziy Co²⁺ ion to‘rtta N-orqali bog‘langan 2a-5mt va bitta apikal Cl⁻ bilan o‘ralgan, erkin Cl⁻ qarshi-ion sifatida mavjud. UB-Vis spektrida 512 nm da d–d o‘tishlari (yuqori spinli d⁷), 261–214 nm da ligand ichidagi π→π* va LMCT bandalari kuzatildi. IQ-spektri N-orqali koordinatsiya (C=N siljishi), kuchli N–H⋯Cl vodorod bog‘lanishlari va Co–N, Co–Cl tebranishlarini tasdiqladi. Hirshfeld sirt tahlili H–H (39.4%), H–S (19%), H–Cl (13.6%) kontaktlarining ustunligini va sirt maydoni 506.68 Ų, hajm 599.75 ų ni ko‘rsatdi. Kompleks 2-aminotiazol metall birikmalariga yaqin bo‘lib, biologik faollik, korroziya inhibitatsiyasi va materialshunoslikda qo‘llanish potentsialiga ega
References
1. Mishra R. et al. Biological potential of thiazole derivatives of synthetic origin //Journal of Heterocyclic Chemistry. – 2017. – Т. 54. – №. 4. – С. 2103-2116.
2. Ramos-Inza S. et al. Thiazole moiety: An interesting scaffold for developing new antitumoral compounds //Heterocycles-synthesis and biological activities. – IntechOpen, 2019.
3. Hsu A., Granneman G. R., Bertz R. J. Ritonavir: clinical pharmacokinetics and interactions with other anti-HIV agents //Clinical pharmacokinetics. – 1998. – Т. 35. – №. 4. – С. 275-291.
4. Pfaller M. A. et al. Antifungal activities of posaconazole, ravuconazole, and voriconazole compared to those of itraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. and other filamentous fungi: report from SENTRY Antimicrobial Surveillance Program, 2000 //Antimicrobial agents and chemotherapy. – 2002. – Т. 46. – №. 4. – С. 1032-1037.
5. Fan L. et al. Nitazoxanide, an anti-parasitic drug, efficiently ameliorates learning and memory impairments in AD model mice //Acta Pharmacologica Sinica. – 2019. – Т. 40. – №. 10. – С. 1279-1291.
6. Del Tacca M. et al. Efficacy and tolerability of meloxicam, a COX-2 preferential nonsteroidal anti-inflammatory drug: A review //Clinical drug investigation. – 2002. – Т. 22. – №. 12. – С. 799-818.
7. Niu J. et al. Screening licorice for H2 receptor-binding anti-ulcer components using affinity chromatography //Journal of Pharmaceutical and Biomedical Analysis. – 2025. – Т. 265. – С. 117058.
8. Shalaby S. E. M., Farrag A. R. H., El-Saed G. S. M. Toxicological potential of thiamethoxam insecticide on albino rats and its residues in some organs //JASMR. – 2010. – Т. 5. – №. 2. – С. 165-172.
9. Arshad M. F. et al. Thiazole: A versatile standalone moiety contributing to the development of various drugs and biologically active agents //Molecules. – 2022. – Т. 27. – №. 13. – С. 3994.
10. Lynch D. E. et al. Molecular co-crystals of 2-aminothiazole derivatives //Structural Science. – 1999. – Т. 55. – №. 5. – С. 758-766.
11. Gomha S. M., Ahmed S. A., Abdelhamid A. O. Synthesis and Cytotoxicity Evaluation of Some Novel Thiazoles, Thiadiazoles, and Pyrido [2, 3-d][1, 2, 4] triazolo [4, 3-a] pyrimidin-5 (1 H)-ones Incorporating Triazole Moiety //Molecules. – 2015. – Т. 20. – №. 1. – С. 1357-1376.
12. Tasnova T. et al. Synthesis and characterization of N-(N-benzoyl thioureido)-1, 3, 4-thiadiazoline compounds of biological interest. – 2017.
13. Turgunov K. K. et al. Stereochemistry of tropane alkaloid of convolvine and their derivatives //European Journal of Chemistry. – 2019. – Т. 10. – №. 4. – С. 376-380.
14. Widdess K. et al. UV-Vis Spectrophotometer Comparison. – 2015.
15. Spackman P. R. et al. CrystalExplorer: a program for Hirshfeld surface analysis, visualization and quantitative analysis of molecular crystals //Applied Crystallography. – 2021. – Т. 54. – №. 3. – С. 1006-1011.
16. Kamalov S. et al. Antimicrobial activity enhancement and acute toxicity lowering of benzamide through preparation of metal complexes //Journal of Molecular Structure. – 2024. – Т. 1303. – С. 137620.
17. Kamolov S. et al. Synthesis, structure and Hirshfeld surface analysis of diaquadinitratobis (4-nitroaniline) copper (II) //Structure Reports. – 2022. – Т. 78. – №. 12. – С. 1165-1168.
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