Keywords
GKMAT
supramolekulyar kompleks
molekulyar nisbat
antioksidantlik faolligi
in vitro
flavonoidlar
erkin radikallar
biologik faol moddalar
DPPH usuli.
How to Cite
Abstract
Ushbu maqolada kaempferol bilan GKMAT ning 1:2 molekulyar nisbatdagi supramolekulyar kompleksining antioksidantlik faolligi izomolyar va in vitro sharoitlarda o‘rganildi. Kaempferol tabiiy flavonoid birikma bo‘lib, kuchli antioksidant xususiyatlarga ega, GKMAT esa biologik faol moddalarning eruvchanligi va biofaolligini oshiruvchi komponent sifatida qo‘llanildi. Tadqiqot davomida kaempferol va GKMAT asosida hosil qilingan supramolekulyar kompleksning fizik-kimyoviy xossalari hamda erkin radikallarni neytrallash qobiliyati turli analitik usullar yordamida baholandi. Kompleksning antioksidantlik faolligi izomolyar tizim va in vitro sharoitlarda DPPH hamda boshqa radikal tutuvchi usullar asosida aniqlanib, natijalar sof kaempferol bilan solishtirildi. Tadqiqot natijalari supramolekulyar kompleks hosil bo‘lishi kaempferolning biologik faolligini oshirishini va uning antioksidantlik xususiyatlarini kuchaytirishini ko‘rsatdi. Olingan ma’lumotlar ushbu kompleksdan farmatsevtika va biotexnologiya sohalarida istiqbolli biologik faol tizim sifatida foydalanish mumkinligini tasdiqlaydi.References
1. Kumar S., Pandey A.K. Chemistry and biological activities of flavonoids: An overview // Scientific World Journal. - 2013. - Vol. 2013. - P. 1-16.
2. Calderón-Montaño J.M., Burgos-Morón E., Pérez-Guerrero C., López-Lázaro M. A review on the dietary flavonoid kaempferol // Mini Reviews in Medicinal Chemistry. - 2011. - Vol. 11. - №4. - P. 298-344.
3. Rice-Evans C.A., Miller N.J., Paganga G. Structure-antioxidant activity relationships of flavonoids and phenolic acids // Free Radical Biology and Medicine. - 1996. - Vol. 20. - №7. - P. 933-956.
4. Lehn J.M. Supramolecular Chemistry: Concepts and Perspectives. – Weinheim: VCH Publishers, 1995. -271 p.
5. Steed J.W., Atwood J.L. Supramolecular Chemistry. – Chichester: John Wiley & Sons, 2009. - 990 p.
6. Liu Z., Jiao Y., Wang Y., Zhou C., Zhang Z. Polysaccharides-based nanoparticles as drug delivery systems // Advanced Drug Delivery Reviews. - 2008. - Vol. 60. - P. 1650-1662.
7. Zhang H., Chen J., Li J. Antioxidant properties of polysaccharide complexes // International Journal of Biological Macromolecules. - 2017. - Vol. 95. - P. 130-136.
8. Stuart B. Infrared Spectroscopy: Fundamentals and Applications. – England: John Wiley & Sons, 2004. - 224 p.
9. Job P. Formation and stability of inorganic complexes in solution // Annali di Chimica Applicata. - 1928. - Vol. 9. - P. 113-203.
10. Misra H.P., Fridovich I. The role of superoxide anion in the autoxidation of epinephrine // Journal of Biological Chemistry. - 1972. - Vol. 247. - №10. - P. 3170-3175.
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Copyright (c) 2026 Xurshida Azimovna Saidova, Akmal Xushvaqtovich Islomov (Author)