Vol. 8 No. 5 (2026), Articles
Vol. 8 No. 5 (2026)

“AS-MIR” OZIQ-OVQAT QOSHILMASINING O‘TKIR ZAHARLILIGI HAMDA YALLIG‘LANISHGA TA’SIRI ANIQLASH

Articles
Published 2026-07-02
Mirzoxidbek Muzafarjon o'g'li Bokiyev
Andijon davlat tibbiyot instituti Biologik kimyo kafedrasi assistenti
https://orcid.org/0000-0002-4221-474X
Ibrohimjon Rahmonovich Asqarov
Andijon davlat universiteti, Kimyo kafedrasi professori, kimyo fanlari doktori, O‘zbekistonda xizmat ko‘rsatgan ixtirochi, O‘zbekiston TABOBAT Akademiyasi raisi
https://orcid.org/0000-0003-1625-0330
Vahobjon Umarovich Xo'jayev
Qo‘qon davlat universiteti professori, kimyo fanlari doktori
https://orcid.org/0009-0001-9922-3989
Irodakhon Yusupovna Mamatova
Andijon davlat tibbiyot instituti Biologik kimyo kafedrasi professori, kimyo fanlari doktori
https://orcid.org/0009-0003-0675-994X
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Keywords

Qizil karam
yerqalampir
AS-MIR ekstrakti
o‘tkir zaharlilik
LD50
karaginin modeli
yallig‘lanishga qarshi faollik
anti-ekssudativ effekt
Laksidol
sulforafan
moyak bezi saratoni
onkoproteksiya.

How to Cite

“AS-MIR” OZIQ-OVQAT QOSHILMASINING O‘TKIR ZAHARLILIGI HAMDA YALLIG‘LANISHGA TA’SIRI ANIQLASH. (2026). Qo‘qon DPI. Ilmiy Xabarlar Jurnali, 8(5), 111-119. https://doi.org/10.70728/a.series.tab.v08.i05.017
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Abstract

Ushbu tadqiqotda xalq tabobatida keng qo‘llaniladigan qizil karam (Brassica oleracea var. capitata f. rubra) yer ustki qismi va yerqalampir (Armoracia rusticana) ildizining 3:1 nisbatdagi aralashmasidan olingan etanolli ekstrakt (AS-MIR) ning o‘tkir zaharliligi va yallig‘lanishga qarshi (anti-ekssudativ) faolligi laboratoriya hayvonlarida o‘rganildi. O‘tkir zaharlilik testi OECD (2001) xalqaro ko‘rsatmalari asosida oq sichqonlarda 5000 mg/kg dozada o‘tkazildi va moddaning o‘rtacha o‘lim dozasi LD50> 5000 mg/kg ekanligi, ya’ni VI sinf (nisbatan zararsiz) birikmalarga mansubligi aniqlandi. Yallig‘lanishga qarshi faollik kalamushlarda "karaginin modeli" yordamida AS-MIR ning 25, 50 va 75 mg/kg dozalarida hamda qiyosiy preparat Laksidol (10 mg/kg) ishtirokida baholandi. Natijalarga ko‘ra, AS-MIR ning 25 mg/kg dozasi karaginin yuborilgandan keyin 3-soatda eng yuqori anti-ekssudativ faollik (58,2%) ko‘rsatdi va samaradorlik jihatidan Laksidol preparati bilan statistik jihatdan deyarli teng qiymatni namoyon etdi. Bundan tashqari, fitokimyoviy tahlillar o‘simliklar tarkibidagi sulforafan, indol-3-karbinol va glyukozinolatlar kompleksi yallig‘lanish o‘choqlarini so‘ndirish bilan bir qatorda, moyak bezi saratoni kabi onkologik kasalliklarda o‘sma hujayralarining proliferatsiyasini tormozlash va detoksifikatsiya jarayonlarini faollashtirishda yuqori istiqbolga ega ekanligini ko‘rsatadi
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Copyright (c) 2026 Mirzoxidbek Muzafarjon o'g'li Bokiyev, Ibrohimjon Rahmonovich Asqarov, Vahobjon Umarovich Xo'jayev, Irodakhon Yusupovna Mamatova (Author)