Abstract
Ushbu sharh maqolada turli xo’jayin o‘simliklardan ajratib olingan 12 ta avlodga mansub endofit mikroorganizmlarning biologik faolligi tahlil qilindi. Olingan natijalar ushbu shtammlar antibakterial, antifungal, antimalarial, yallig‘lanishga qarshi hamda saratonga qarshi faollik namoyon etishini ko‘rsatdi. Bu ularning biofaol ikkilamchi metabolitlar ishlab chiqarish salohiyatiga ega ekanligidan dalolat beradi. Shuningdek, aniqlangan faolliklar endofit mikroorganizmlarning metabolik xilma-xilligi va ekologik moslashuvchanligini aks ettiradi. Tadqiqot natijalari endofit mikroorganizmlarning farmatsevtika va biotexnologiya sohalaridagi istiqbolini tasdiqlaydi.References
1. Rustamova, N., et al., Biotransformation of natural compounds by fungal microorganisms and their biological activities. Ann Phytomed, 2025. 14: p. 396-411.
2. Murodullayev, D., ENDOFIT MIKROORGANIZMLAR YORDAMIDA TABIIY BIRIKMALARNING MODIFIKATSIYASI VA BIOLOGIK FAOLLIKLARI. 2024-YIL 4-SON (2024/4) OZIQ-OVQAT XAVFSIZLIGI: MILLIY VA GLOBAL MUAMMOLAR Учредители: Samarkand State University, 2025. 1(140/1): p. 72-89.
3. Feng, X., et al., Growth-Promoting Effects of Dark Septate Endophytes Fungus Acrocalymma on Tomato (Solanum lycopersicum). Journal of Fungi, 2025. 11(7): p. 510.
4. Lin, L.-B., et al., Two new steroids with cytotoxicities from fungus Acrocalymma cycadis. Phytochemistry Letters, 2024. 61: p. 298-303.
5. Ahmadpour, A., et al., Morphological and phylogenetic analyses of Bipolaris species associated with Poales and Asparagales host plants in Iran. Frontiers in Cellular and Infection Microbiology, 2025. 15: p. 1520125.
6. Shen, Y., et al., Bipolaristeroid A, a 5,6-seco-9,10-seco-steroid with cytotoxic activity from the fungus Bipolaris maydis. Phytochemistry, 2025. 229: p. 114303.
7. Zhang, Q., et al., Chemical and bioactive diversities of the genus Chaetomium secondary metabolites. Mini reviews in medicinal chemistry, 2012. 12(2): p. 127-148.
8. Zhao, M., et al., Two new cytochalasins from Chaetomium sp. Strain. Tetrahedron Letters, 2024. 137: p. 154936.
9. Chen, Y., et al., Irpexols A-C, xanthone derivatives from the endophyte fungus Irpex laceratus A878. Fitoterapia, 2024. 175: p. 105952.
10. Solarte, F., et al., Diversity of Neopestalotiopsis and Pestalotiopsis spp., causal agents of guava scab in Colombia. Plant Disease, 2018. 102(1): p. 49-59.
11. Abulaizi, A., et al., Isolation and biological activity of six new polyketide and terpenoid derivatives from Neopestalotiopsis Clavispora AL01. Fitoterapia, 2024. 177: p. 106130.
12. Chen, H.-W., et al., Terricoxanthones A–E, unprecedented dihydropyran-containing dimeric xanthones from the endophytic fungus Neurospora terricola HDF-Br-2 associated with the vulnerable conifer Pseudotsuga gaussenii. Phytochemistry, 2024. 219: p. 113963.
13. Yadav, A.N., et al., Biodiversity of the genus Penicillium in different habitats, in New and future developments in microbial biotechnology and bioengineering. 2018, Elsevier. p. 3-18.
14. Wang, J.-W., et al., Alkaloid-metabolites from the mangrove-derived fungus Penicillium robsamsonii HNNU0006. Fitoterapia, 2024. 175: p. 105906.
15. Ying, Y., et al., Secondary metabolites from Penicillium sp. HS-11, a fungal endophyte of Huperzia serrata. Fitoterapia, 2024. 175: p. 105943.
16. Wang, D., et al., Five previously undescribed citrinin derivatives from the endophytic fungus Penicillium citrinum GZWMJZ-836. Phytochemistry, 2024. 220: p. 114032.
17. Chen, Z., et al., Penicipyrrolizidinones A−C, three pyrrolizidinone alkaloids with unprecedented skeletons from the mangrove-derived fungus Penicillium sp. DM27. Phytochemistry, 2025. 229: p. 114273.
18. Han, S., et al., Andrastin-type meroterpenoids, α-pyrone polyketides, and sesquicarane derivatives from Penicillium sp., a fungus isolated from Pinus koraiensis seed. Phytochemistry, 2024. 225: p. 114202.
19. Lindsay, C.A., et al., Steroids and Epicoccarines from Penicillium aurantiancobrunneum. Phytochemistry Letters, 2024. 63: p. 79-86.
20. Chen, H.-W., et al., Undescribed polyketides from endophytes associated with the critically endangered conifer Abies beshanzuensis. Fitoterapia, 2024. 177: p. 106104.
21. Miao, F.-P., et al., Penicianstinoids F-K, six undescribed meroterpenoids from the marine algicolous fungus Penicillium sp. RR-DL-1-7. Fitoterapia, 2024. 177: p. 106110.
22. Qin, Y.-Y., et al., Four new meroterpenoid derivatives with cytotoxicity from the mangrove-derived fungus Penicillium sp. HLLG-122. Fitoterapia, 2025. 183: p. 106494.
23. Pliego, C., et al., Developing tools to unravel the biological secrets of Rosellinia necatrix, an emergent threat to woody crops. Molecular Plant Pathology, 2012. 13(3): p. 226-239.
24. Gu, G., et al., Rosellichalasins A–H, cytotoxic cytochalasans from the endophytic fungus Rosellinia sp. Glinf021. Phytochemistry, 2024. 222: p. 114103.
25. Simons, V.E., et al., Colletodiol derivatives of the endophytic fungus Trichocladium sp. Fitoterapia, 2024. 175: p. 105914.
26. Chen, Q., et al., Trichothecroamides A‒F, antifungal amides from potato associated fungus Trichothecium crotocinigenum. Phytochemistry, 2025. 234: p. 114438.
27. Sun, B.-D., et al., New section and species in Talaromyces. MycoKeys, 2020. 68: p. 75.
28. Zhu, S., et al., Four new polyketides from an endophytic fungus Talaromyces muroii. Fitoterapia, 2024. 177: p. 106073.
29. Chen, W., et al., Structures and biological activities of secondary metabolites from Xylaria spp. Journal of Fungi, 2024. 10(3): p. 190.
30. Wei, S.-S., et al., Sesquiterpenes and α-pyrones from an endophytic fungus Xylaria curta YSJ-5. Phytochemistry, 2024. 220: p. 114011