Abstract
Ushbu tadqiqot ishida yurak-qon tomir kasalliklarida muhim o‘rin tutuvchi silliq muskul hujayralarining qisqarish jarayoniga biologik faol modda sifatida qaraladigan 1-O-Galloil-4,6-geksagidroksidifenoil-β-D-glyukoza (1-GT) gidrolizlanuvchi taninining vazorelaksant ta’sirini o‘rganishdan iborat. Silliq muskul hujayralarining qisqarishi asosan sitozolda joylashgan sarkoplazmatik retikulumdan kalsiy ionlarining chiqarilishi bilan bog‘liq bo‘lgani uchun, ushbu moddaning aynan Ca2+ dinamikasiga ta’siri alohida tahlil qilindi. Tadqiqotning asosiy maqsadi 1-GT ning past konsentratsiyalarda tomir devori silliq mushaklarini bo‘shashtirish qobiliyatini baholash va uning potensial antigipertenziv xususiyatlarini aniqlashdir. Taninning vazorelaksant effekti qon tomir tonusining pasayishi, periferik qarshilikning kamayishi va arterial bosimni me’yorga tushirishda muhim ahamiyat kasb etadi. Ushbu ish natijalari tabiiy kelib chiqishga ega gidrolizlanuvchi taninlarning yuqori samarali va xavfsiz antigipertenziv modda sifatida qo‘llanish imkoniyatlarini aniqlashga xizmat qiladi. Bundan tashqari, tadqiqot kelajakda yangi biologik faol yondashuvlar, tabiiy polifenollar asosidagi dorivor vositalarni ishlab chiqish uchun ilmiy asos yaratadi.References
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