Abstract
Leyshmanioz dunyo bo‘yicha keng tarqalgan parazitar kasalliklardan biri bo‘lib, tropik va subtropik hududlarda muhim epidemiologik muammo hisoblanadi. Ushbu kasallik Leishmania jinsiga mansub protozoa parazitlari tomonidan chaqiriladi va asosan Phlebotomus urug‘iga mansub hashoratlar orqali tashiladi. Tadqiqotning maqsadi visseral leyshmanioz kasalligining epidemiologik xususiyatlarini, uning tarqalishiga ta‘sir qiluvchi omillarni hamda zamonaviy davolash usullarining samaradorligini tahlil qilishdan iborat. Tadqiqot davomida ilmiy adabiyotlar, xalqaro epidemiologik hisobotlar va sog‘liqni saqlash tashkilotlarining statistik ma‘lumotlari tahlil qilindi. Natijalar shuni ko‘rsatdiki, leyshmanioz asosan ijtimoiy-iqtisodiy sharoiti past bo‘lgan hududlarda keng tarqalgan bo‘lib, iqlim o‘zgarishi va urbanizatsiya jarayonlari kasallikning geografik tarqalish hududini kengaytirmoqda. Shuningdek, antimonial preparatlar, Amphotericin B va Miltefosine kabi dori vositalari davolashda samarali bo‘lsa-da, ularning toksikligi va narxi muayyan muammolarni keltirib chiqarmoqda. Tadqiqot natijalari visseral leyshmaniozga qarshi kurashishda erta diagnostika, samarali davolash strategiyalari va profilaktika choralarini kuchaytirish zarurligini ko‘rsatadi.References
1. World Health Organization. Leishmaniasis: Epidemiology and Access to Medicines. Geneva: WHO Press, 2023.
2. World Health Organization. Control of the Leishmaniases. WHO Technical Report Series
949. Geneva, 2010.
3. Higashi G. I.. Immunodiagnostic tests for protozoan and helminthic infections. Diagnostic Immunology. 1984;2(1):2–18.
4. Centers for Disease Control and Prevention. Leishmaniasis: Resources for Health Professionals. Atlanta, 2022.
5. Sundar S., Chakravarty J.. An update on pharmacotherapy for leishmaniasis. Expert Opinion on Pharmacotherapy. 2015.
6. London School of Hygiene & Tropical Medicine. Clinical studies on liposomal amphotericin B in leishmaniasis treatment, 2018–2022.
7. All India Instituti of Medical Sciences. Miltefosine in the treatment of visceral leishmaniasis. New Delhi, 2019.
8. Samarqand davlat tibbiyot universiteti. Teri leyshmaniozi bo‘yicha epidemiologik tadqiqotlar to‘plami. Samarqand, 2021–2024.
9. O‘zbekiston Respublikasi Sanitariya-epidemiologik osoyishtalik va jamoat salomatligi qo‘mitasi. Leyshmanioz bo‘yicha milliy hisobotlar. Toshkent, 2022–2024.
10. Alvar J. va boshqalar. Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE. 2012.