Keywords
2-d]pyrimidinones
polycyclic heterocycles
brominated heterocycles
cyclocondensation
α-methylene condensation
arylidene derivatives.
How to Cite
Abstract
A concise synthetic route was developed for brominated polycyclic thieno[3,2-d]pyrimidinones through sequential cyclocondensation and α-methylene condensation. Ethyl 3-amino-5-bromobenzo[b]thiophene-2-carboxylate was prepared from 5- bromo-2-chlorobenzonitrile and ethyl 2-mercaptoacetate under basic conditions. Subsequent reactions with cyclic lactams afforded fused derivatives with different ring sizes. Condensation with aromatic aldehydes provided arylidene products. Structural characterization by 1H/13C NMR spectroscopy and HRMS confirmed the proposed molecular frameworks, establishing a practical platform for further functionalization.References
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