Keywords
flavonoidlar
liquiritin
isoliquiritin
liquiritigenin
isoliquiritigenin
glabridin
ekologik omillar
geografik o‘zgaruvchanlik
kimyoviy marker
HPLC
UHPLC-MS
standartlashtirish.
How to Cite
Abstract
Glycyrrhiza glabra L. (Fabaceae) farmakologik ahamiyatga ega ikkilamchi metabolitlarga boy dorivor o‘simlik hisoblanadi. So‘nggi xromatografik va mass- spektrometrik tadqiqotlar flavonoidlar G. glabra ning muhim biofaol komponentlari ekanligini ko‘rsatmoqda. Liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin va glabridin miqdori geografik kelib chiqish, tuproq-iqlim sharoiti, namlik, harorat va vegetatsiya bosqichiga bog‘liq ravishda o‘zgarishi mumkin. Mazkur maqolada G. glabra flavonoid tarkibining ekologik va geografik o‘zgaruvchanligi zamonaviy xromatografik, mass-spektrometrik va metabolomik tadqiqotlar asosida tanqidiy tahlil qilindi. Adabiyotlar tahlili turli geografik populyatsiyalarni yagona analitik protokol asosida qiyoslash, flavonoidlarning miqdoriy nisbatlarini ekologik omillar bilan bog‘lash va hududga xos barqaror kimyoviy markerlarni aniqlash masalalari yetarlicha o‘rganilmaganligini ko‘rsatdi. Ayniqsa, O‘zbekiston hududida tarqalgan G. glabra populyatsiyalarini HPLC/ UHPLC-MS asosida qiyosiy tadqiq etish dolzarb hisoblanadi. Liquiritin-isoliquiritin-liquiritigenin-isoliquiritigenin-glabridin tizimidan ko‘p komponentli kimyoviy marker sifatida foydalanish xomashyoni geografik autentifikatsiya qilish, sifatini baholash va standartlashtirish uchun istiqbolli yondashuv sifatida asoslandi.References
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